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GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.
Couto Alves, Alexessander; De Silva, N Maneka G; Karhunen, Ville; Sovio, Ulla; Das, Shikta; Taal, H Rob; Warrington, Nicole M; Lewin, Alexandra M; Kaakinen, Marika; Cousminer, Diana L; Thiering, Elisabeth; Timpson, Nicholas J; Bond, Tom A; Lowry, Estelle; Brown, Christopher D; Estivill, Xavier; Lindi, Virpi; Bradfield, Jonathan P; Geller, Frank; Speed, Doug; Coin, Lachlan J M; Loh, Marie; Barton, Sheila J; Beilin, Lawrence J; Bisgaard, Hans; Bønnelykke, Klaus; Alili, Rohia; Hatoum, Ida J; Schramm, Katharina; Cartwright, Rufus; Charles, Marie-Aline; Salerno, Vincenzo; Clément, Karine; Claringbould, Annique A J; van Duijn, Cornelia M; Moltchanova, Elena; Eriksson, Johan G; Elks, Cathy; Feenstra, Bjarke; Flexeder, Claudia; Franks, Stephen; Frayling, Timothy M; Freathy, Rachel M; Elliott, Paul; Widén, Elisabeth; Hakonarson, Hakon; Hattersley, Andrew T; Rodriguez, Alina; Banterle, Marco; Heinrich, Joachim.
Afiliação
  • Couto Alves A; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • De Silva NMG; School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
  • Karhunen V; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Sovio U; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Das S; Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK.
  • Taal HR; NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
  • Warrington NM; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Lewin AM; MRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK.
  • Kaakinen M; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
  • Cousminer DL; Department of Paediatrics, Erasmus MC, Sophia Children's Hospital, Rotterdam, Netherlands.
  • Thiering E; Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.
  • Timpson NJ; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
  • Bond TA; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Lowry E; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.
  • Brown CD; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
  • Estivill X; Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK.
  • Lindi V; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Surrey, UK.
  • Bradfield JP; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Geller F; Institute of Biomedicine, Department of Physiology, University of Eastern Finland, Kuopio, Finland.
  • Speed D; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
  • Coin LJM; Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich Neuherberg, Germany.
  • Loh M; Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children's Hospital, Ludwig-Maximilians University Munich, Munich, Germany.
  • Barton SJ; MRC Integrative Epidemiology Unit at the University of Bristol and NIHR Bristol Biomedical Research Center, Bristol, UK.
  • Beilin LJ; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
  • Bisgaard H; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Bønnelykke K; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
  • Alili R; Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Hatoum IJ; Genomics and Disease Group, Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), Barcelona, Catalonia, Spain.
  • Schramm K; Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain.
  • Cartwright R; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain.
  • Charles MA; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Salerno V; Institute of Biomedicine, Department of Physiology, University of Eastern Finland, Kuopio, Finland.
  • Clément K; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Claringbould AAJ; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • van Duijn CM; UCL Genetics Institute, University College London, London, UK.
  • Moltchanova E; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Eriksson JG; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  • Elks C; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Feenstra B; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
  • Flexeder C; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (ASTAR) Singapore, Singapore.
  • Franks S; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
  • Frayling TM; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Freathy RM; Medical School, Royal Perth Hospital, University of Western Australia, Perth, Western Australia, Australia.
  • Elliott P; COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Widén E; COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Hakonarson H; CRNH Ile de France, Hôpital Pitié-Salpêtrière, Paris, France.
  • Hattersley AT; CRNH Ile de France, Hôpital Pitié-Salpêtrière, Paris, France.
  • Rodriguez A; Obesity, Metabolism, and Nutrition Institute and Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA.
  • Banterle M; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Heinrich J; Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Sci Adv ; 5(9): eaaw3095, 2019 09.
Article em En | MEDLINE | ID: mdl-31840077
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Índice de Massa Corporal / Característica Quantitativa Herdável / Locos de Características Quantitativas / Estudo de Associação Genômica Ampla / Estudos de Associação Genética Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Child / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Índice de Massa Corporal / Característica Quantitativa Herdável / Locos de Características Quantitativas / Estudo de Associação Genômica Ampla / Estudos de Associação Genética Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Child / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article