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Vaginal dose of radical radiotherapy for cervical cancer in China: a multicenter study.
Wang, Juan; Zhang, Kai-Shuo; Wang, Tao; Liu, Zi; Wang, Rui-Hua; Zhang, Fu-Quan; Yu, Lang; Ran, Li; He, Jian-Li; Wang, Ya-Li; Wei, Li-Chun; Shi, Mei; Wang, Guo-Qing; Wu, Chao-Qun; Kang, Qi-Jun; Yang, Jie; Li, Sha; Yang, Fei-Yue; Liu, Bao-Gang; Liu, Juan-Yue; Shi, Fan; Su, Jin; Yuan, Wei; Drokow, Emmanuel Kwateng.
Afiliação
  • Wang J; Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiao Tong University, 277# West Yanta Road, Xi'an, Shaanxi, China.
  • Zhang KS; Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiao Tong University, 277# West Yanta Road, Xi'an, Shaanxi, China.
  • Wang T; Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiao Tong University, 277# West Yanta Road, Xi'an, Shaanxi, China.
  • Liu Z; Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiao Tong University, 277# West Yanta Road, Xi'an, Shaanxi, China. liuzmail@163.com.
  • Wang RH; Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiao Tong University, 277# West Yanta Road, Xi'an, Shaanxi, China.
  • Zhang FQ; Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100032, China.
  • Yu L; Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100032, China.
  • Ran L; Department of Oncology, The Affiliated Hospital of Guizhou Medical Universty/Guizhou Cancer Hospital, Gui Yang, 550000, China.
  • He JL; Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yin chuan, 750004, China.
  • Wang YL; Department of Radiation Oncology, The Second Affiliated hospital of Xi'an Jiao Tong University, Xi'an, 710004, China.
  • Wei LC; Department of Radiation Oncology, First Affiliated Hospital of Air Force Medical University, Xi'an, 710032, China.
  • Shi M; Department of Radiation Oncology, First Affiliated Hospital of Air Force Medical University, Xi'an, 710032, China.
  • Wang GQ; Department of Gynecology Oncology, Shaanxi Provincial Tumor Hospital, Xi'an, 710061, China.
  • Wu CQ; Department of Radiation Oncology, The first people's Hospital of Kashi District, Xinjiang, 844000, China.
  • Kang QJ; Department of Radiation Oncology, The first people's Hospital of Kashi District, Xinjiang, 844000, China.
  • Yang J; Department of Radiation Oncology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, 830002, China.
  • Li S; Department of Radiation Oncology, The 940th Hospital of Joint Logistics Support force of Chinese People's Liberation Army, Lan Zhou, 730050, China.
  • Yang FY; Department of Oncology, Guizhou Provincial People's Hospital, Guiyang, 550002, China.
  • Liu BG; Department of Radiation Oncology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xian yang, 712046, China.
  • Liu JY; Department of Radiation Oncology, Xi'an Gao Xin Hospital, Xi'an, 710000, China.
  • Shi F; Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiao Tong University, 277# West Yanta Road, Xi'an, Shaanxi, China.
  • Su J; Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiao Tong University, 277# West Yanta Road, Xi'an, Shaanxi, China.
  • Yuan W; Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiao Tong University, 277# West Yanta Road, Xi'an, Shaanxi, China.
  • Drokow EK; Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiao Tong University, 277# West Yanta Road, Xi'an, Shaanxi, China.
BMC Cancer ; 19(1): 1219, 2019 Dec 16.
Article em En | MEDLINE | ID: mdl-31842811
ABSTRACT

BACKGROUND:

The posterior-inferior border of symphysis (PIBS) point system is a novel vaginal dose-reporting method and is a simple and reliable method proposed by the Medical University of Vienna proposed for both external-beam radiotherapy (EBRT) and brachytherapy (BT). In this multicenter study, we sought to first evaluate the vaginal radiation dose in Chinese cervical cancer patients according to the PIBS point system and then to analyze the factors influencing the dose distribution.

METHODS:

We collected data from the medical records of 936 cervical cancer patients who underwent concurrent radiochemotherapy at 13 different institutions in China. Radiation doses at points A, PIBS+ 2 cm, PIBS and PIBS-2 cm, International Commission on Radiation Units (ICRU)-R and ICRU-B were measured.

RESULTS:

The median total doses in EQD2α/ß = 3 at points PIBS+ 2 cm, PIBS and PIBS-2 cm were 82.5 (52.7-392.1) Gy, 56.2 (51.4-82.1) Gy and 2.6 (0.9-7.4) Gy, respectively. The median total doses in EQD2α/ß = 3 at ICRU-R and ICRU-B were 77.5 (54.8-132.4) Gy and 79.9 (60.7-133.7) Gy, respectively. The mean vaginal reference length (VRL) was 4.6 ± 1.0 cm (median, 4.5 cm). In patients with VRL ≤4.5 cm, the mean total doses in EQD2α/ß = 3 at points PIBS+ 2 cm, PIBS and PIBS-2 cm were 128.5, 60.7 and 0.8 Gy, respectively. In patients with VRL > 4.5 cm, the mean total doses at these three points were 68.9, 0.5 and 54.5 Gy, respectively. Classification of patients revealed significant differences (P < 0.05) between these two groups.

CONCLUSIONS:

With the PIBS point system, Chinese patients with a shorter VRL of < 4.5 cm received higher radiation doses at the PIBS+ 2 cm, PIBS and PIBS-2 cm points than European and American patients. Further studies are required to establish the dose-effect relationships with these points as references. The study was registered as a clinical trial (NCT03257475) on August 22, 2017.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Braquiterapia / Neoplasias do Colo do Útero / Quimiorradioterapia Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Middle aged País como assunto: Asia Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Braquiterapia / Neoplasias do Colo do Útero / Quimiorradioterapia Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Middle aged País como assunto: Asia Idioma: En Ano de publicação: 2019 Tipo de documento: Article