Intergenerational associations of dietary inflammatory index with birth outcomes and weight status at age 5 and 9: Results from the Lifeways cross-generation cohort study.
Pediatr Obes
; 15(3): e12588, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-31845544
ABSTRACT
BACKGROUND:
Maternal diet and chronic inflammation may influence early-life offspring health. No comparative data regarding intergenerational associations between dietary inflammation and offspring growth exist.OBJECTIVE:
To investigate potential associations between parental and grandparental dietary inflammatory index (DII®) scores with offspring birth outcomes and childhood adiposity.METHODS:
This analysis of the Lifeways Study includes 1082 mother-child pairs, 333 index-child's fathers and 707 grandparents. Energy-adjusted DII (E-DII) scores were derived from a validated FFQ for all adults. Birth outcomes were abstracted from hospital records. Childhood BMI was determined at age 5 and 9. Logistic regression and mediation analyses using the PROCESS macro for SPSS were performed.RESULTS:
Higher maternal E-DII scores, reflecting a more pro-inflammatory diet, were associated with increased risk of low birthweight (LBW), BW < 2500 g (OR1.20, 95%CI1.02-1.47, p = 0.03). Higher maternal grandmothers' (MGM) E-DII scores were associated with increased risk of macrosomia (OR1.35, 95% CI1.02-1.79, p = 0.03) and with increased risk of an overweight grandchild at age 9 (OR1.47, 95% CI1.26-1.72, p = 0.02). Results from the mediation analyses revealed a significant total effect between MGMs' E-DII scores and grandchild's BW. Higher father's and paternal grandmothers' (PGM) E-DII scores were associated with greater risk of childhood overweight/obesity at 5 years (OR1.03, 95%CI1.01-1.19, p = 0.04 and OR1.07, 95%CI1.05-1.09, p = 0.01, respectively). The association with the PGMs' E-DII persisted at age 9 (OR1.13, 95%CI1.01-1.90, p = 0.04).CONCLUSIONS:
Dietary inflammation is associated with adverse offspring birth outcomes and childhood adiposity. A more pro-inflammatory maternal line diet appears to influence early-life growth, whereas paternal line dietary inflammation appears to influence childhood obesity.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dieta
/
Sobrepeso
/
Obesidade Infantil
/
Inflamação
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article