Exposure to Organophosphate Pesticides and Menstrual Cycle Characteristics in Chinese Preconceptional Women.
Am J Epidemiol
; 189(5): 375-383, 2020 05 05.
Article
em En
| MEDLINE
| ID: mdl-31845721
ABSTRACT
Organophosphates (OPs) are the most heavily used pesticides in China. The Chinese population, including preconceptional women, is highly exposed, yet little is known regarding the associations between OP exposure and menstruation in humans. We conducted a cross-sectional analysis in women preparing for pregnancy to investigate the relationship between biomarkers of OP exposure and menstrual cycle characteristics. From 2013 to 2015, 627 women visiting free preconception-care clinics at 2 maternity hospitals in Shanghai, China, were included. Information on menstrual cycle characteristics was obtained through questionnaires. OP exposure was assessed by measuring urine concentrations of 6 dialkylphosphate metabolites (dimethylphosphate, dimethylthiophosphate, dimethyldithiophosphate, diethylphosphate, diethylthiophosphate, and diethyldithiophosphate). The relationship between concentrations of dialkylphosphate metabolites and menstrual cycle characteristics was analyzed using multiple linear regression models and logistic regression models. Log-transformed levels of diethyl phosphate metabolites (the sum of diethylphosphate and diethylthiophosphate levels) were related to a higher risk of irregularity of menstrual cycles (adjusted odds ratio = 2.36, 95% confidence interval 1.28, 4.34). Subjects with a higher concentration of diethyl phosphate metabolites (log-transformed) had a shorter duration of menstrual bleeding (adjusted ß = -0.33, 95% confidence interval -0.64, -0.02). The findings suggest that OP exposure may be associated with alterations in menstrual function in preconceptional women.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Praguicidas
/
Organofosfatos
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Cuidado Pré-Concepcional
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Poluentes Ambientais
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Ciclo Menstrual
Tipo de estudo:
Prognostic_studies
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Qualitative_research
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Risk_factors_studies
/
Screening_studies
Limite:
Adult
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Female
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Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article