Extragonadal Steroids Contribute Significantly to Androgen Receptor Activity and Development of Castration Resistance in Recurrent Prostate Cancer after Primary Therapy.

Pouliot, Frédéric; Rouleau, Mélanie; Neveu, Bertrand; Toren, Paul; Morin, Fannie; Vélot, Lauriane; Ding, Keyue; Caron, Patrick; Lacombe, Louis; Lévesque, Éric; Klotz, Laurence; Guillemette, Chantal

Pouliot, Frédéric; Rouleau, Mélanie; Neveu, Bertrand; Toren, Paul; Morin, Fannie; Vélot, Lauriane; Ding, Keyue; Caron, Patrick; Lacombe, Louis; Lévesque, Éric; Klotz, Laurence; Guillemette, Chantal.

Afiliação

Pouliot F; Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Ontario, Canada.
Rouleau M; Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Ontario, Canada.
Neveu B; Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Ontario, Canada.
Toren P; Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Ontario, Canada.
Morin F; Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Ontario, Canada.
Vélot L; Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Ontario, Canada.
Ding K; NCIC Clinical Trials Group, Queen's University, Kingston, Ontario, Canada.
Caron P; Pharmacy Faculty, Université Laval and CHU de Québec-Université Laval, Québec, Ontario, Canada.
Lacombe L; Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Ontario, Canada.
Lévesque É; Medicine Faculty, Université Laval and CHU de Québec-Université Laval, Québec, Ontario, Canada.
Klotz L; Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Guillemette C; Pharmacy Faculty, Université Laval and CHU de Québec-Université Laval, Québec, Ontario, Canada.

J Urol ; 203(5): 940-948, 2020 05.

Article em En | MEDLINE | ID: mdl-31845837

Assuntos

Androstenodiona/farmacologia; Castração/métodos; Recidiva Local de Neoplasia/terapia; Neoplasias da Próstata/terapia; Receptores Androgênicos/metabolismo; Testosterona/análogos & derivados; Testosterona/farmacologia; Anabolizantes/farmacologia; Androgênios/farmacologia; Biomarcadores Tumorais/metabolismo; Linhagem Celular Tumoral; Seguimentos; Humanos; Masculino; Espectrometria de Massas; Recidiva Local de Neoplasia/metabolismo; Recidiva Local de Neoplasia/patologia; Estudos Prospectivos; Próstata/efeitos dos fármacos; Próstata/metabolismo; Próstata/patologia; Neoplasias da Próstata/metabolismo; Neoplasias da Próstata/patologia; Receptores Androgênicos/efeitos dos fármacos; Fatores de Tempo

Palavras-chave

androgen; luminescence; mass spectrometry; prostatic neoplasms; receptors; steroids

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Testosterona / Castração / Receptores Androgênicos / Androstenodiona / Recidiva Local de Neoplasia Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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