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Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019.
Haller, Sebastian; Kramer, Rolf; Becker, Karsten; Bohnert, Jürgen A; Eckmanns, Tim; Hans, Jörg B; Hecht, Jane; Heidecke, Claus-Dieter; Hübner, Nils-Olaf; Kramer, Axel; Klaper, Kathleen; Littmann, Martina; Marlinghaus, Lennart; Neumann, Bernd; Pfeifer, Yvonne; Pfennigwerth, Niels; Rogge, Simone; Schaufler, Katharina; Thürmer, Andrea; Werner, Guido; Gatermann, Sören.
Afiliação
  • Haller S; Robert Koch Institute, Department for Infectious Disease Epidemiology, Berlin, Germany.
  • Kramer R; Robert Koch Institute, Department for Infectious Disease Epidemiology, Berlin, Germany.
  • Becker K; University Medicine Greifswald, Greifswald, Germany.
  • Bohnert JA; University Medicine Greifswald, Greifswald, Germany.
  • Eckmanns T; Robert Koch Institute, Department for Infectious Disease Epidemiology, Berlin, Germany.
  • Hans JB; National Reference Centre for multidrug-resistant Gram-negative bacteria, Ruhr University Bochum, Bochum, Germany.
  • Hecht J; Robert Koch Institute, Department for Infectious Disease Epidemiology, Berlin, Germany.
  • Heidecke CD; University Medicine Greifswald, Greifswald, Germany.
  • Hübner NO; University Medicine Greifswald, Greifswald, Germany.
  • Kramer A; University Medicine Greifswald, Greifswald, Germany.
  • Klaper K; Robert Koch Institute, Division of Nosocomial Pathogens and Antibiotic Resistance, Wernigerode, Germany.
  • Littmann M; Regional Public Health Authority Mecklenburg-Western Pomerania, Rostock, Germany.
  • Marlinghaus L; National Reference Centre for multidrug-resistant Gram-negative bacteria, Ruhr University Bochum, Bochum, Germany.
  • Neumann B; Robert Koch Institute, Division of Nosocomial Pathogens and Antibiotic Resistance, Wernigerode, Germany.
  • Pfeifer Y; Robert Koch Institute, Division of Nosocomial Pathogens and Antibiotic Resistance, Wernigerode, Germany.
  • Pfennigwerth N; National Reference Centre for multidrug-resistant Gram-negative bacteria, Ruhr University Bochum, Bochum, Germany.
  • Rogge S; Regional Public Health Authority Mecklenburg-Western Pomerania, Rostock, Germany.
  • Schaufler K; Institute of Pharmacy, University of Greifswald, Greifswald, Germany.
  • Thürmer A; Robert Koch Institute, Genome Sequencing Unit, Berlin, Germany.
  • Werner G; Robert Koch Institute, Division of Nosocomial Pathogens and Antibiotic Resistance, Wernigerode, Germany.
  • Gatermann S; National Reference Centre for multidrug-resistant Gram-negative bacteria, Ruhr University Bochum, Bochum, Germany.
Euro Surveill ; 24(50)2019 Dec.
Article em En | MEDLINE | ID: mdl-31847948
ABSTRACT
From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) Klebsiella pneumoniae strain were notified from four Western Pomerania medical facilities. The XDR K. pneumoniae produced carbapenemases NDM-1 and OXA-48, and was only susceptible to chloramphenicol, tigecycline and cefiderocol. Synergistic activity was observed for the combination of aztreonam plus ceftazidime-avibactam. Genomic analyses showed all isolates belonged to K. pneumoniae sequence type 307. Control measures and further investigations are ongoing.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Infecções por Klebsiella / Infecção Hospitalar / Surtos de Doenças / Klebsiella pneumoniae / Antibacterianos Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Infecções por Klebsiella / Infecção Hospitalar / Surtos de Doenças / Klebsiella pneumoniae / Antibacterianos Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article