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Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression.
Hitora, Yuki; Takada, Kentaro; Ise, Yuji; Woo, Sau Pinn; Inoue, Seiya; Mori, Naoki; Takikawa, Hirosato; Nakamukai, Shohei; Okada, Shigeru; Matsunaga, Shigeki.
Afiliação
  • Hitora Y; Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
  • Takada K; Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. Electronic address: ktakada@kitasato-u.ac.jp.
  • Ise Y; Sugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University, Sugashima-cho, Toba-shi, Mie 517-0004, Japan.
  • Woo SP; Center for Marine and Coastal Studies, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.
  • Inoue S; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bukyo-ku, Tokyo 113-8657, Japan.
  • Mori N; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bukyo-ku, Tokyo 113-8657, Japan.
  • Takikawa H; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bukyo-ku, Tokyo 113-8657, Japan.
  • Nakamukai S; Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
  • Okada S; Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
  • Matsunaga S; Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. Electronic address: assmats@mail.ecc.-tokyo.ac.jp.
Bioorg Med Chem ; 28(2): 115233, 2020 01 15.
Article em En | MEDLINE | ID: mdl-31848114
ABSTRACT
New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poríferos / Sesquiterpenos / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poríferos / Sesquiterpenos / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article