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The small fiber neuropathy NaV1.7 I228M mutation: impaired neurite integrity via bioenergetic and mitotoxic mechanisms, and protection by dexpramipexole.
Lee, Seong-Il; Hoeijmakers, Janneke G J; Faber, Catharina G; Merkies, Ingemar S J; Lauria, Giuseppe; Waxman, Stephen G.
Afiliação
  • Lee SI; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut.
  • Hoeijmakers JGJ; Center for Neuroscience and Regeneration Research, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut.
  • Faber CG; Department of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The Netherlands.
  • Merkies ISJ; Department of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The Netherlands.
  • Lauria G; Department of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The Netherlands.
  • Waxman SG; Department of Neurology, Curaçao Medical Center, Willemstad, Curaçao.
J Neurophysiol ; 123(2): 645-657, 2020 02 01.
Article em En | MEDLINE | ID: mdl-31851560
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trifosfato de Adenosina / Neuritos / Fármacos Neuroprotetores / Canal de Sódio Disparado por Voltagem NAV1.7 / Neuropatia de Pequenas Fibras / Pramipexol / Gânglios Espinais / Mitocôndrias / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trifosfato de Adenosina / Neuritos / Fármacos Neuroprotetores / Canal de Sódio Disparado por Voltagem NAV1.7 / Neuropatia de Pequenas Fibras / Pramipexol / Gânglios Espinais / Mitocôndrias / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article