Anti-cyclic citrullinated peptide antibody predicts the development of rheumatoid arthritis in patients with undifferentiated arthritis.
Chin Med J (Engl)
; 132(24): 2899-2904, 2019 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-31855969
ABSTRACT
BACKGROUND:
Clinical outcomes of undifferentiated arthritis (UA) are diverse, and only 40% of patients with UA develop rheumatoid arthritis (RA) after 3 years. Discovering predictive markers at disease onset for further intervention is critical. Therefore, our objective was to analyze the clinical outcomes of UA and ascertain the predictors for RA development.METHODS:
We performed a prospective, multi-center study from January 2013 to October 2016 among Chinese patients diagnosed with UA in 22 tertiary-care hospitals. Clinical and serological parameters were obtained at recruitment. Follow-up was undertaken in all patients every 12 weeks for 2 years. Predictive factors of disease progression were identified using multivariate Cox proportional hazards regression.RESULTS:
A total of 234 patients were recruited in this study, and 17 (7.3%) patients failed to follow up during the study. Among the 217 patients who completed the study, 83 (38.2%) patients went into remission. UA patients who developed RA had a higher rheumatoid factor (RF)-positivity (42.9% vs. 16.8%, χâ=â8.228, Pâ=â0.008), anti-cyclic citrullinated peptide (CCP) antibody-positivity (66.7% vs. 10.7%, χâ=â43.897, Pâ<â0.001), and double-positivity rate of RF and anti-CCP antibody (38.1% vs. 4.1%, χâ=â32.131, Pâ<â0.001) than those who did not. Anti-CCP antibody but not RF was an independent predictor for RA development (hazard ratio 18.017, 95% confidence interval 5.803-55.938; Pâ<â0.001).CONCLUSION:
As an independent predictor of RA, anti-CCP antibody should be tested at disease onset in all patients with UA.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
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Artrite
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Artrite Reumatoide
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Autoanticorpos
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article