Pathogenesis, disease course, and prognosis of adult-onset Still's disease: an update and review.
Chin Med J (Engl)
; 132(23): 2856-2864, 2019 Dec 05.
Article
em En
| MEDLINE
| ID: mdl-31856058
ABSTRACT
OBJECTIVE:
Adult-onset Still's disease (AOSD) is a rare but clinically well-known polygenic systemic autoinflammatory disease. In this review, we aim to present frontiers in the pathogenesis, clinical features, diagnosis, biomarkers, disease course, prognosis, and treatment in AOSD. DATA SOURCES We retrieved information from the PubMed database up to July 2019, using various search terms and relevant words, including AOSD and Still's disease. STUDY SELECTION We included data from peer-reviewed journals. Both basic and clinical studies were selected.RESULTS:
Pathogenesis of AOSD involves genetic background, infectious triggers, and immunopathogenesis, mainly the activation of macrophages and neutrophils followed by a cytokine storm. Diagnosis and prognosis evaluation of AOSD is still challenging; therefore, there is an urgent need to identify better biomarkers. Biologic agents, including interleukin (IL)-1ß, IL-6, and tumor necrosis factor-α antagonists in the treatment of AOSD, have good prospect.CONCLUSION:
This review highlights the advances in pathogenesis, potential biomarkers, disease course, and treatment in AOSD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Still de Início Tardio
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article