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A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.
Le Nours, Jérôme; Gherardin, Nicholas A; Ramarathinam, Sri H; Awad, Wael; Wiede, Florian; Gully, Benjamin S; Khandokar, Yogesh; Praveena, T; Wubben, Jacinta M; Sandow, Jarrod J; Webb, Andrew I; von Borstel, Anouk; Rice, Michael T; Redmond, Samuel J; Seneviratna, Rebecca; Sandoval-Romero, Maria L; Li, Shihan; Souter, Michael N T; Eckle, Sidonia B G; Corbett, Alexandra J; Reid, Hugh H; Liu, Ligong; Fairlie, David P; Giles, Edward M; Westall, Glen P; Tothill, Richard W; Davey, Martin S; Berry, Richard; Tiganis, Tony; McCluskey, James; Pellicci, Daniel G; Purcell, Anthony W; Uldrich, Adam P; Godfrey, Dale I; Rossjohn, Jamie.
Afiliação
  • Le Nours J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • Gherardin NA; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
  • Ramarathinam SH; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia.
  • Awad W; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, Victoria 3010, Australia.
  • Wiede F; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • Gully BS; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • Khandokar Y; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • Praveena T; Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.
  • Wubben JM; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • Sandow JJ; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
  • Webb AI; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • von Borstel A; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • Rice MT; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • Redmond SJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  • Seneviratna R; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia.
  • Sandoval-Romero ML; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  • Li S; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia.
  • Souter MNT; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • Eckle SBG; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
  • Corbett AJ; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • Reid HH; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
  • Liu L; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia.
  • Fairlie DP; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia.
  • Giles EM; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • Westall GP; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia.
  • Tothill RW; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, Victoria 3010, Australia.
  • Davey MS; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia.
  • Berry R; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia.
  • Tiganis T; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia.
  • McCluskey J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
  • Pellicci DG; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.
  • Purcell AW; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Uldrich AP; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Brisbane, Queensland 4072, Australia.
  • Godfrey DI; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Rossjohn J; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Brisbane, Queensland 4072, Australia.
Science ; 366(6472): 1522-1527, 2019 12 20.
Article em En | MEDLINE | ID: mdl-31857486
ABSTRACT
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We describe a diverse population of human γδ T cells isolated from peripheral blood and tissues that exhibit autoreactivity to the monomorphic MHC-related protein 1 (MR1). The crystal structure of a γδTCR-MR1-antigen complex starkly contrasts with all other TCR-MHC and TCR-MHC-I-like complex structures. Namely, the γδTCR binds underneath the MR1 antigen-binding cleft, where contacts are dominated by the MR1 α3 domain. A similar pattern of reactivity was observed for diverse MR1-restricted γδTCRs from multiple individuals. Accordingly, we simultaneously report MR1 as a ligand for human γδ T cells and redefine the parameters for TCR recognition.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Classe I / Antígenos de Histocompatibilidade Menor / Receptores de Antígenos de Linfócitos T gama-delta / Apresentação de Antígeno Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Classe I / Antígenos de Histocompatibilidade Menor / Receptores de Antígenos de Linfócitos T gama-delta / Apresentação de Antígeno Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article