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VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease.
Kim, Jeonghan; Gupta, Rajeev; Blanco, Luz P; Yang, Shutong; Shteinfer-Kuzmine, Anna; Wang, Kening; Zhu, Jun; Yoon, Hee Eun; Wang, Xinghao; Kerkhofs, Martijn; Kang, Hyeog; Brown, Alexandra L; Park, Sung-Jun; Xu, Xihui; Zandee van Rilland, Eddy; Kim, Myung K; Cohen, Jeffrey I; Kaplan, Mariana J; Shoshan-Barmatz, Varda; Chung, Jay H.
Afiliação
  • Kim J; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
  • Gupta R; Department of Life Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
  • Blanco LP; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20982, USA.
  • Yang S; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
  • Shteinfer-Kuzmine A; Department of Life Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
  • Wang K; Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
  • Zhu J; Systems Biology Center, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
  • Yoon HE; Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, and Leuven Kanker Instituut, KU Leuven, 3000 Leuven, Belgium.
  • Wang X; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
  • Kerkhofs M; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20982, USA.
  • Kang H; Mokobio Biotechnology R&D Center, Rockville, MD 20850, USA.
  • Brown AL; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
  • Park SJ; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
  • Xu X; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
  • Zandee van Rilland E; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
  • Kim MK; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
  • Cohen JI; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
  • Kaplan MJ; Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
  • Shoshan-Barmatz V; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20982, USA.
  • Chung JH; Department of Life Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Science ; 366(6472): 1531-1536, 2019 12 20.
Article em En | MEDLINE | ID: mdl-31857488
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Membranas Mitocondriais / Canais de Ânion Dependentes de Voltagem / Multimerização Proteica / Lúpus Eritematoso Sistêmico Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Membranas Mitocondriais / Canais de Ânion Dependentes de Voltagem / Multimerização Proteica / Lúpus Eritematoso Sistêmico Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article