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Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy.
Ogata, Hidenori; Isobe, Noriko; Zhang, Xu; Yamasaki, Ryo; Fujii, Takayuki; Machida, Akira; Morimoto, Nobutoshi; Kaida, Kenichi; Masuda, Teruaki; Ando, Yukio; Kuwahara, Motoi; Kusunoki, Susumu; Nakamura, Yuri; Matsushita, Takuya; Kira, Jun-Ichi.
Afiliação
  • Ogata H; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: hidenori@neuro.med.kyushu-u.ac.jp.
  • Isobe N; Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: kuroki@neuro.med.kyushu-u.ac.jp.
  • Zhang X; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: shu-@neuro.med.kyushu-u.ac.jp.
  • Yamasaki R; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: ryoya@neuro.med.kyushu-u.ac.jp.
  • Fujii T; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: takayuki@neuro.med.kyushu-u.ac.jp.
  • Machida A; Department of Neurology, Tsuchiura Kyodo General Hospital, Ibaraki 300-0028, Japan. Electronic address: akinuro@tmd.ac.jp.
  • Morimoto N; Department of Neurology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, Japan.
  • Kaida K; Department of Neurology, Anti-aging and Vascular Medicine, National Defense Medical College, Saitama 359-8513, Japan. Electronic address: adiak901@ndmc.ac.jp.
  • Masuda T; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan. Electronic address: tmasu93@kuh.kumamoto-u.ac.jp.
  • Ando Y; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan. Electronic address: andoy709@kumamoto-u.ac.jp.
  • Kuwahara M; Department of Neurology, School of Medicine, Kindai University, Osaka, 589-8511, Japan. Electronic address: kuwahara@med.kindai.ac.jp.
  • Kusunoki S; Department of Neurology, School of Medicine, Kindai University, Osaka, 589-8511, Japan. Electronic address: kusunoki-tky@umin.ac.jp.
  • Nakamura Y; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: nakayuri@neuro.med.kyushu-u.ac.jp.
  • Matsushita T; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: matusita@neuro.med.kyushu-u.ac.jp.
  • Kira JI; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: kira@neuro.med.kyushu-u.ac.jp.
J Neuroimmunol ; 339: 577139, 2020 02 15.
Article em En | MEDLINE | ID: mdl-31864140
To clarify the immunogenetic background of patients with immunoglobulin G (IgG)4 anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP), we genotyped the extended human leukocyte antigen (HLA) haplotypes in 22 Japanese patients with this disorder and compared them with those of healthy Japanese controls. All IgG4 anti-NF155 antibody-positive CIDP patients exclusively carried either HLA-DRB1*15:01-DRB5*01:01-DQA1*01:02-DQB1*06:02 or -(A*24:02)-B*52:01-C*12:02-DRB1*15:02-DRB5*01:02-DQA1*01:03-DQB1*06:01, resulting in significantly increased HLA-DRB1*15, -DRB1*15:01, -DQB1*06:01/06:02, -DQB1*06:02, and -DRB1*15:01-DQB1*06:02 frequencies compared with healthy Japanese controls. These findings indicate the involvement of specific HLA class II molecules in the pathomechanisms of IgG4 anti-NF155 antibody-positive CIDP.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autoanticorpos / Haplótipos / Imunoglobulina G / Moléculas de Adesão Celular / Polirradiculoneuropatia Desmielinizante Inflamatória Crônica / Antígenos HLA / Fatores de Crescimento Neural Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autoanticorpos / Haplótipos / Imunoglobulina G / Moléculas de Adesão Celular / Polirradiculoneuropatia Desmielinizante Inflamatória Crônica / Antígenos HLA / Fatores de Crescimento Neural Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article