[Study on quality of standard decoction of Coptidis Rhizoma based on traditional decoction process].
Zhongguo Zhong Yao Za Zhi
; 44(18): 3985-3993, 2019 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-31872735
ABSTRACT
In order to determine the quality evaluation method for standard decoction of Coptidis Rhizoma,15 batches of standard decoction of Coptidis Rhizoma were prepared by using standardized process. Parameters such as traits,p H value,indicative component content,fingerprint similarity,composition transfer rate and dry extract rate were selected as the indexes for quality evaluation. Similarity evaluation and cluster analysis were performed for HPLC fingerprint of standard decoction,and mathematical model was used to study the correlation between dry extract rate,berberine content,berberine transfer rate in standard decoction and berberine content in decoction pieces. The results showed that the similarity of fingerprints was greater than 0. 99 for these 15 batches of standard decoctions of Coptidis Rhizoma. In cluster analysis,the standard decoctions of Coptidis Rhizoma from 4 producing areas were classified into 3 categories,consistent with the content determination results,indicating that there were quality differences among different producing areas.R2 in three linear regression mathematical models established was all greater than 0. 9,with significant difference. The validation of three batches of data showed that the models had good accuracy. Therefore,this model can be used to predict the quality of standard decoction prepared from different Coptidis Rhizoma pieces. In the standard decoction process established in this study,the integrity of the traditional process was greatly preserved,and the established quality evaluation method could be used to comprehensively examine the quality of the standard decoction,which can provide a demonstration for the related research of water extraction preparation containing Coptidis Rhizoma pieces.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Controle de Qualidade
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Berberina
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Medicamentos de Ervas Chinesas
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Coptis
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Ano de publicação:
2019
Tipo de documento:
Article