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Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.
Kim, Kidae; Lee, Dong Ho; Park, Sungryul; Jo, Seung-Hyun; Ku, Bonsu; Park, Sung Goo; Park, Byoung Chul; Jeon, Yeong Uk; Ahn, Sunjoo; Kang, Chung Hyo; Hwang, Daehee; Chae, Sehyun; Ha, Jae Du; Kim, Sunhong; Hwang, Jong Yeon; Kim, Jeong-Hoon.
Afiliação
  • Kim K; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea.
  • Lee DH; Department of Proteome Structural biology, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, Republic of Korea.
  • Park S; Therapeutics & Biotechnology, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
  • Jo SH; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea.
  • Ku B; Department of Proteome Structural biology, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, Republic of Korea.
  • Park SG; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea.
  • Park BC; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, Republic of Korea.
  • Jeon YU; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea.
  • Ahn S; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea.
  • Kang CH; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, Republic of Korea.
  • Hwang D; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea.
  • Chae S; Department of Proteome Structural biology, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, Republic of Korea.
  • Ha JD; Therapeutics & Biotechnology, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
  • Kim S; Therapeutics & Biotechnology, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
  • Hwang JY; Department of Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon, 34113, Republic of Korea.
  • Kim JH; Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
Sci Rep ; 9(1): 19654, 2019 12 23.
Article em En | MEDLINE | ID: mdl-31873151
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Ubiquitina-Proteína Ligases / Proteínas Adaptadoras de Transdução de Sinal / Proteólise Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Ubiquitina-Proteína Ligases / Proteínas Adaptadoras de Transdução de Sinal / Proteólise Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article