Nascent-HBr-Catalyzed Removal of Orthogonal Protecting Groups in Aqueous Surfactants.
J Org Chem
; 85(4): 2635-2645, 2020 02 21.
Article
em En
| MEDLINE
| ID: mdl-31875403
Organic reactions in the aqueous environment have recently emerged as a promising research area. The generation of nascent-HBr from the slow hydrolysis of the dispersed catalyst, benzyl bromide, with the interior water present in the hydrophobic core of the confined micellar medium in aqueous surfactant is described for the first time. The sustained-release nascent-HBr enabled the chemoselective cleavages of acid-sensitive orthogonal functionalities present in carbohydrates, amino alcohols, and hydroxylated acyclic compounds in good to excellent yields.
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MEDLINE
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En
Ano de publicação:
2020
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Article