Further characterization of the synergistic activation mechanism of cationic channels by M<sub>2</sub> and M<sub>3</sub> muscarinic receptors in mouse intestinal smooth muscle cells.

Tanahashi, Yasuyuki; Katsurada, Taisuke; Inasaki, Noriko; Uchiyama, Mai; Sakamoto, Takashi; Yamamoto, Masayuki; Matsuyama, Hayato; Komori, Seiichi; Unno, Toshihiro

Further characterization of the synergistic activation mechanism of cationic channels by M₂ and M₃ muscarinic receptors in mouse intestinal smooth muscle cells.

Tanahashi, Yasuyuki; Katsurada, Taisuke; Inasaki, Noriko; Uchiyama, Mai; Sakamoto, Takashi; Yamamoto, Masayuki; Matsuyama, Hayato; Komori, Seiichi; Unno, Toshihiro.

Afiliação

Tanahashi Y; Department of Animal Medical Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan.
Katsurada T; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Inasaki N; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Uchiyama M; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Sakamoto T; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Yamamoto M; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Matsuyama H; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Komori S; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Unno T; Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.

Am J Physiol Cell Physiol ; 318(3): C514-C523, 2020 03 01.

Article em En | MEDLINE | ID: mdl-31875697

Assuntos

Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP/metabolismo; Mucosa Intestinal/metabolismo; Miócitos de Músculo Liso/metabolismo; Receptor Muscarínico M2/metabolismo; Receptor Muscarínico M3/metabolismo; Animais; Agonistas Colinérgicos/farmacologia; Relação Dose-Resposta a Droga; Feminino; Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP/agonistas; Cobaias; Mucosa Intestinal/citologia; Mucosa Intestinal/efeitos dos fármacos; Masculino; Camundongos; Camundongos da Linhagem 129; Camundongos Knockout; Miócitos de Músculo Liso/citologia; Miócitos de Músculo Liso/efeitos dos fármacos; Peptídeos Cíclicos/farmacologia; Receptor Muscarínico M2/agonistas; Receptor Muscarínico M3/agonistas

Palavras-chave

YM-254890; intestinal smooth muscle; muscarinic receptor; muscarinic receptor knockout mouse; nonselective cationic current

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP / Miócitos de Músculo Liso / Receptor Muscarínico M2 / Receptor Muscarínico M3 / Mucosa Intestinal Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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