SNX16 activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of eEF1A2 in colorectal cancer development.

Shen, Zhiyong; Li, Yongsheng; Fang, Yuan; Lin, Mingdao; Feng, Xiaochuang; Li, Zhenkang; Zhan, Yizhi; Liu, Yuechen; Mou, Tingyu; Lan, Xiaoliang; Wang, Yanan; Li, Guoxin; Wang, Jiping; Deng, Haijun

Shen, Zhiyong; Li, Yongsheng; Fang, Yuan; Lin, Mingdao; Feng, Xiaochuang; Li, Zhenkang; Zhan, Yizhi; Liu, Yuechen; Mou, Tingyu; Lan, Xiaoliang; Wang, Yanan; Li, Guoxin; Wang, Jiping; Deng, Haijun.

Afiliação

Shen Z; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Li Y; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Fang Y; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Lin M; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Feng X; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Li Z; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhan Y; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Liu Y; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Mou T; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Lan X; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wang Y; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Li G; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wang J; Division of Surgical Oncology, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Deng H; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Mol Oncol ; 14(2): 387-406, 2020 02.

Article em En | MEDLINE | ID: mdl-31876369

Assuntos

Carcinogênese/genética; Neoplasias Colorretais/metabolismo; Fator 1 de Elongação de Peptídeos/metabolismo; Complexo de Endopeptidases do Proteassoma/metabolismo; Proteínas Proto-Oncogênicas c-myc/metabolismo; Nexinas de Classificação/metabolismo; Ubiquitina/metabolismo; Idoso; Animais; Apoptose/genética; Pontos de Checagem do Ciclo Celular/genética; Linhagem Celular Tumoral; Proliferação de Células/genética; Neoplasias Colorretais/genética; Neoplasias Colorretais/mortalidade; Feminino; Humanos; Imuno-Histoquímica; Masculino; Espectrometria de Massas; Camundongos; Camundongos Nus; Pessoa de Meia-Idade; Modelos de Riscos Proporcionais; Complexo de Endopeptidases do Proteassoma/genética; Estabilidade Proteica; Transdução de Sinais/genética; Nexinas de Classificação/genética; Regulação para Cima; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

SNX16; c-Myc; cell proliferation; colorectal cancer; eEF1A2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteínas Proto-Oncogênicas c-myc / Fator 1 de Elongação de Peptídeos / Ubiquitina / Complexo de Endopeptidases do Proteassoma / Nexinas de Classificação / Carcinogênese Tipo de estudo: Prognostic_studies Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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