Direct Decarboxylative Functionalization of Carboxylic Acids via O-H Hydrogen Atom Transfer.
J Am Chem Soc
; 142(1): 44-49, 2020 01 08.
Article
em En
| MEDLINE
| ID: mdl-31877036
ABSTRACT
Decarboxylative functionalization via hydrogen atom transfer offers an attractive alternative to standard redox approaches to this important class of transformations. Herein, we report a direct decarboxylative functionalization of aliphatic carboxylic acids using N-xanthylamides. The unique reactivity of amidyl radicals in hydrogen atom transfer enables decarboxylative xanthylation under redox-neutral conditions. This platform provides expedient access to a range of derivatives through subsequent elaboration of the xanthate group.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Carboxílicos
/
Hidrogênio
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article