Simultaneous germline and somatic sequencing in ovarian carcinoma: mutation rate and impact on clinical decision-making.

Jorge, Soledad; McFaddin, Andrew S; Doll, Kemi M; Pennington, Kathryn P; Norquist, Barbara M; Bennett, Robin L; Pritchard, Colin C; Swisher, Elizabeth M

Jorge, Soledad; McFaddin, Andrew S; Doll, Kemi M; Pennington, Kathryn P; Norquist, Barbara M; Bennett, Robin L; Pritchard, Colin C; Swisher, Elizabeth M.

Afiliação

Jorge S; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195, United States of America. Electronic address: sjorge@uw.edu.
McFaddin AS; Division of Molecular Diagnostics, Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, United States of America.
Doll KM; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195, United States of America.
Pennington KP; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195, United States of America.
Norquist BM; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195, United States of America.
Bennett RL; Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, United States of America.
Pritchard CC; Division of Molecular Diagnostics, Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, United States of America.
Swisher EM; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195, United States of America.

Gynecol Oncol ; 156(3): 517-522, 2020 03.

Article em En | MEDLINE | ID: mdl-31883735

Assuntos

Carcinoma Epitelial do Ovário/genética; Tomada de Decisão Clínica/métodos; Testes Genéticos/métodos; Mutação; Neoplasias Ovarianas/genética; Adulto; Idoso; Proteína BRCA1/genética; Proteína BRCA2/genética; Carcinoma Epitelial do Ovário/patologia; Carcinoma Epitelial do Ovário/terapia; Feminino; Genes BRCA1; Genes BRCA2; Mutação em Linhagem Germinativa; Humanos; Pessoa de Meia-Idade; Taxa de Mutação; Recidiva Local de Neoplasia/genética; Estadiamento de Neoplasias; Neoplasias Ovarianas/patologia; Neoplasias Ovarianas/terapia

Palavras-chave

BRCA; BROCA; Genetic testing; Germline; Ovarian cancer; Somatic

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Testes Genéticos / Tomada de Decisão Clínica / Carcinoma Epitelial do Ovário / Mutação Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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