Non-canonical (non-SMAD2/3) TGF-ß signaling in fibrosis: Mechanisms and targets.
Semin Cell Dev Biol
; 101: 115-122, 2020 05.
Article
em En
| MEDLINE
| ID: mdl-31883994
ABSTRACT
Transforming growth factor (TGF)-ß uses several intracellular signaling pathways besides canonical ALK5-Smad2/3 signaling to regulate a diverse array of cellular functions. Several of these so-called non-canonical (non-Smad2/3) pathways have been implicated in the pathogenesis of fibrosis and may therefore represent targets for therapeutic intervention. This review summarizes our current knowledge on the mechanisms of non-canonical TGF-ß signaling in fibrosis, the potential molecular targets and the use of agonists/antagonists for therapeutic intervention.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibrose
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Transdução de Sinais
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Fator de Crescimento Transformador beta
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article