New Promise and Opportunities for Allosteric Kinase Inhibitors.

Lu, Xiaoyun; Smaill, Jeff B; Ding, Ke

Lu, Xiaoyun; Smaill, Jeff B; Ding, Ke.

Afiliação

Lu X; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of PR China, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, 510632, China.
Smaill JB; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
Ding K; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of PR China, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, 510632, China.

Angew Chem Int Ed Engl ; 59(33): 13764-13776, 2020 08 10.

Article em En | MEDLINE | ID: mdl-31889388

Assuntos

Inibidores de Proteínas Quinases/farmacologia; Regulação Alostérica; Animais; Humanos; Estrutura Molecular; Inibidores de Proteínas Quinases/química; Proteólise; Especificidade por Substrato

Palavras-chave

allosteric kinase inhibitors; drug design; extracellular domain; kinase domain; pseudokinase domain

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google