The Relationship Between IDH1 Mutation Status and Metabolic Imaging in Nonenhancing Supratentorial Diffuse Gliomas: A 11C-MET PET Study.
Mol Imaging
; 18: 1536012119894087, 2019.
Article
em En
| MEDLINE
| ID: mdl-31889470
ABSTRACT
PURPOSE:
We evaluated the relationship between isocitrate dehydrogenase 1 (IDH1) mutation status and metabolic imaging in patients with nonenhancing supratentorial diffuse gliomas using 11C-methionine positron emission tomography (11C-MET PET). MATERIALS ANDMETHODS:
Between June 2012 and November 2017, we enrolled 86 (38 women and 48 men; mean age, 41.9 ± 13.1 years [range, 8-67 years]) patients with newly diagnosed supratentorial diffuse gliomas. All patients underwent preoperative 11C-MET PET. Tumor samples were obtained and immunohistochemically analyzed for IDH1 mutation status.RESULTS:
The mutant and wild-type IDH1 diffuse gliomas had significantly different mean maximum standardized uptake value values (2.73 [95% confidence interval, CI 2.32-3.16] vs 3.85 [95% CI 3.22-4.51], respectively; P = .004) and mean tumor-to-background ratio (1.90 [95% CI 1.65-2.16] vs 2.59 [95% CI 2.17-3.04], respectively; P = .007).CONCLUSIONS:
11C-methionine PET can noninvasively evaluate the IDH1 mutation status of patients with nonenhancing supratentorial diffuse gliomas.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tomografia Computadorizada por Raios X
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Tomografia por Emissão de Pósitrons
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Isocitrato Desidrogenase
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Metionina
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Mutação
Tipo de estudo:
Observational_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article