Positive prostate biopsy following radiotherapy can predict metastasis-free survival in localized prostate cancer.
Rep Pract Oncol Radiother
; 25(1): 55-59, 2020.
Article
em En
| MEDLINE
| ID: mdl-31889922
ABSTRACT
BACKGROUND/AIMS:
To determine the impact of post-treatment biopsy results on 10-year metastasis-free survival (MFS), overall survival (OS) and cause-specific survival (CSS) in localized prostate cancer (PCa) patients treated with high-dose radiotherapy (RT). MATERIALS/METHODS:
Retrospective analysis of 232 patients with T1c-T3bN0M0 PCa who underwent a prostate biopsy 24-36 months after high-dose RT. Biopsies were categorized as positive biopsy (PB) if H&E staining showed evidence of residual malignancy and negative biopsy (NB) if no malignant cells were present. Kaplan-Meier estimates of 10-year MFS, OS and CSS rates were calculated for each group and Cox proportional-hazards models were used to estimate the hazard ratios. The median follow-up was 124 months (range 26-267).RESULTS:
Sixty-two of 232 (26.7%) patients had post-treatment positive biopsies (PB). A positive post-treatment biopsy was significantly associated with a lower 10-year MFS (78.4% vs. 95.4%, pâ¯=â¯0.001, HR 3.9, 95% CI 1.8-8.3). Although patients with PB had worse outcomes that those with NB, we could not show a statistically significant difference in OS (81.0% vs. 87.9%, pâ¯=â¯0.282, HR 1.3, 95% CI 0.7-2.3) or CSS (96.2% vs. 99.4% (pâ¯=â¯0.201, HR. 2.4, 95% CI 0.6-9.7). After multivariate analysis, the strongest predictor of MFS was the post-treatment biopsy status (pâ¯<â¯0.001, HR 5.4, 95% CI 2.26-12.85) followed by Gleason score (pâ¯=â¯0.002, HR 2.24, 95% CI 1.33-3.79).CONCLUSION:
A positive biopsy following RT can predict MFS in localized prostate cancer. These data highlight the relevance of achieving a local control and support the use of aggressive local therapeutic interventions for PCa.
Texto completo:
1
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article