Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus.
J Int Med Res
; 48(4): 300060519870407, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-31891278
ABSTRACT
OBJECTIVE:
To investigate the relationships among serum resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus (T2DM).METHODS:
A total of 120 patients with T2DM were divided into non-microangiopathy and microangiopathy groups. Sixty age- and sex-matched healthy subjects were used as a normal control (NC) group. Body height, body mass, waist circumference, and blood pressure were determined, and waist/hip ratio (WHR), body mass index, blood glucose, lipids, resistin, leptin, adiponectin, free fatty acids (FFA), high-sensitivity C-reactive protein (hs-CRP), fasting insulin, hemoglobin A1c, and homeostatic model assessment of insulin resistance (HOMA-IR) were compared among the three groups.RESULTS:
Serum levels of resistin, leptin, FFA, and hs-CRP were significantly higher and levels of adiponectin were significantly lower in patients in the non-microangiopathy (n = 60) and microangiopathy groups (n = 60) compared with the NC group (n = 60). Serum resistin and leptin levels in patients with T2DM were positively correlated with WHR, hs-CRP, FFA, HOMA-IR, and triglycerides, but negatively correlated with high-density lipoprotein-cholesterol (HDL-C). Serum adiponectin levels in patients with T2DM were negatively correlated with WHR, hs-CRP, FFA, HOMA-IR, and triglycerides, but positively correlated with HDL-C.CONCLUSION:
Serum resistin, adiponectin, and leptin levels correlate with the occurrence of T2DM and microvascular complications.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Vasculares
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Leptina
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Diabetes Mellitus Tipo 2
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Adiponectina
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Resistina
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article