Intraflagellar transport 20: New target for the treatment of ciliopathies.
Biochim Biophys Acta Mol Cell Res
; 1867(7): 118641, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-31893523
ABSTRACT
Cilia are ubiquitous in mammalian cells. The formation and assembly of cilia depend on the normal functioning of the ciliary transport system. In recent years, various proteins involved in the intracellular transport of the cilium have attracted attention, as many diseases are caused by disorders in cilia formation. Intraflagellar transport 20 (IFT20) is a subunit of IFT complex B, which contains approximately 20 protein particles. Studies have shown that defects in IFT20 are associated with numerous system -related diseases, such as those of the urinary system, cardiovascular system, skeletal system, nervous system, immune system, reproductive system, and respiratory system. This review summarizes current research on IFT20.We describe studies related to the role of IFT20 in cilia formation and discuss new targets for treating diseases associated with ciliary dysplasia.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transporte Biológico
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Proteínas de Transporte
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Cílios
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Ciliopatias
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article