Stereoselective Michael additions on α-aminoacrylates as the key step to an l-Oic analogue bearing a quaternary stereocenter.
Org Biomol Chem
; 18(4): 671-674, 2020 01 28.
Article
em En
| MEDLINE
| ID: mdl-31894826
ABSTRACT
A novel, highly stereoselective route for pharmaceutically relevant octahydroindole-2-carboxylates bearing a quaternary stereocenter has been developed. The key chiral intermediates 3 have been prepared in good yields and enantiomeric excesses up to 98%. A broad substrate range has been tolerated under the reaction conditions.
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Base de dados:
MEDLINE
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En
Ano de publicação:
2020
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Article