Continuous Radio Amplification by Stimulated Emission of Radiation using Parahydrogen Induced Polarization (PHIP-RASER) at 14 Tesla.
Chemphyschem
; 21(7): 667-672, 2020 04 02.
Article
em En
| MEDLINE
| ID: mdl-31898393
ABSTRACT
Nuclear Magnetic Resonance (NMR) is an intriguing quantum-mechanical effect that is used for routine medical diagnostics and chemical analysis alike. Numerous advancements have contributed to the success of the technique, including hyperpolarized contrast agents that enable real-time imaging of metabolism inâ
vivo. Herein, we report the finding of an NMR radio amplification by stimulated emission of radiation (RASER), which continuously emits 1 H NMR signal for more than 10â
min. Using parahydrogen induced hyperpolarization (PHIP) with 50 % para-hydrogen, we demonstrated the effect at 600â
MHz but expect that it is functional across a wide range of frequencies, e.g. 101 -103 â
MHz. PHIP-RASER occurs spontaneously or can be triggered with a standard NMR excitation. Full chemical shift resolution was maintained, and a linewidth of 0.6â
ppb was achieved. The effect was reproduced by simulations using a weakly coupled, two spin- 1/2 system. All devices used were standard issue, such that the effect can be reproduced by any NMR lab worldwide with access to liquid nitrogen for producing parahydrogen.
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2020
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Article