Self-assembled biomimetic Nano-Matrix for stem cell anchorage.
J Biomed Mater Res A
; 108(4): 984-991, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-31904174
ABSTRACT
Mesenchymal stem cells (MSCs) have been widely applied in biomedicine due to their ability to differentiate into many different cell types and their ability to synthesize a broad spectrum of growth factors and cytokines that directly and indirectly influence other cells in their vicinity. To guide MSC infiltration to a bone fracture site, we developed a novel self-assembled Nano-Matrix which can be used as an injectable scaffold to repair bone fractures. The Nano-Matrix is formed by Janus base nanotubes (JBNTs) and fibronectin (FN). JBNTs are nucleobase-derived nanotubes mimicking collagen fibers, and FN is one of the cell adhesive glycoproteins which is responsible for cell-extracellular matrix interactions and guides stem cell migration and differentiation to desired cells types. Here, we demonstrated the successful fabrication and characterization of the JBNT/FN Nano-Matrix as well as its excellent bioactivity that encouraged human MSC migration and adhesion. This work lays a solid foundation for using the Nano-Matrix as an injectable approach to improve MSC retention and function during bone fracture healing.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Materiais Biomiméticos
/
Nanopartículas
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Células-Tronco Mesenquimais
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article