Soybean lecithin stabilizes disulfiram nanosuspensions with a high drug-loading content: remarkably improved antitumor efficacy.

Li, Haowen; Liu, Biao; Ao, Hui; Fu, Jingxin; Wang, Yian; Feng, Yue; Guo, Yifei; Wang, Xiangtao

Li, Haowen; Liu, Biao; Ao, Hui; Fu, Jingxin; Wang, Yian; Feng, Yue; Guo, Yifei; Wang, Xiangtao.

Afiliação

Li H; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, People's Republic of China.
Liu B; Harbin University of Commerce China, Research Center ON Life Sciences and Environmental Sciences, Harbin, 150076, People's Republic of China.
Ao H; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, People's Republic of China.
Fu J; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, People's Republic of China.
Wang Y; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, People's Republic of China.
Feng Y; Guangdong Jiabo Pharmaceutical CO., LTD, Jianshe 3rd Road, Hi-tech Industrial Development Zone, Qingyuan, 511517, Guangdong, People's Republic of China.
Guo Y; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, People's Republic of China. ffguo@163.com.
Wang X; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, People's Republic of China. xtaowang@163.com.

J Nanobiotechnology ; 18(1): 4, 2020 Jan 06.

Article em En | MEDLINE | ID: mdl-31907045

Assuntos

Antineoplásicos/farmacologia; Dissulfiram/farmacologia; Glycine max/química; Lecitinas/química; Nanopartículas/química; Animais; Varredura Diferencial de Calorimetria; Linhagem Celular Tumoral; Dissulfiram/química; Liberação Controlada de Fármacos; Estabilidade de Medicamentos; Feminino; Camundongos Endogâmicos BALB C; Nanopartículas/ultraestrutura; Tamanho da Partícula; Eletricidade Estática; Suspensões; Distribuição Tecidual/efeitos dos fármacos; Resultado do Tratamento; Difração de Raios X

Palavras-chave

4T1 cells; Breast cancer; Disulfiram; Nanosuspensions; Soybean lecithin (SPC)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glycine max / Dissulfiram / Nanopartículas / Lecitinas / Antineoplásicos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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