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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
Miyagawa, Toji; Brushaber, Danielle; Syrjanen, Jeremy; Kremers, Walter; Fields, Julie; Forsberg, Leah K; Heuer, Hilary W; Knopman, David; Kornak, John; Boxer, Adam; Rosen, Howard J; Boeve, Bradley F; Appleby, Brian; Bordelon, Yvette; Bove, Jessica; Brannelly, Patrick; Caso, Christina; Coppola, Giovanni; Dever, Reilly; Dheel, Christina; Dickerson, Bradford; Dickinson, Susan; Dominguez, Sophia; Domoto-Reilly, Kimiko; Faber, Kelley; Ferrell, Jessica; Fishman, Ann; Fong, Jamie; Foroud, Tatiana; Gavrilova, Ralitza; Gearhart, Debra; Ghazanfari, Behnaz; Ghoshal, Nupur; Goldman, Jill S; Graff-Radford, Jonathan; Graff-Radford, Neill; Grant, Ian; Grossman, Murray; Haley, Dana; Hsiung, Robin; Huey, Edward; Irwin, David; Jones, David; Jones, Lynne; Kantarci, Kejal; Karydas, Anna; Kaufer, Daniel; Kerwin, Diana; Kraft, Ruth; Kramer, Joel.
Afiliação
  • Miyagawa T; Mayo Clinic, Rochester, Minnesota, USA.
  • Brushaber D; Mayo Clinic, Rochester, Minnesota, USA.
  • Syrjanen J; Mayo Clinic, Rochester, Minnesota, USA.
  • Kremers W; Mayo Clinic, Rochester, Minnesota, USA.
  • Fields J; Mayo Clinic, Rochester, Minnesota, USA.
  • Forsberg LK; Mayo Clinic, Rochester, Minnesota, USA.
  • Heuer HW; University of California San Francisco, San Francisco, California, USA.
  • Knopman D; Mayo Clinic, Rochester, Minnesota, USA.
  • Kornak J; University of California San Francisco, San Francisco, California, USA.
  • Boxer A; University of California San Francisco, San Francisco, California, USA.
  • Rosen HJ; University of California San Francisco, San Francisco, California, USA.
  • Boeve BF; Mayo Clinic, Rochester, Minnesota, USA.
  • Appleby B; Case Western Reserve University, Cleveland, Ohio, USA.
  • Bordelon Y; University of California Los Angeles, Los Angeles, California, USA.
  • Bove J; University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Brannelly P; Tau Consortium, Rainwater Charitable Foundation, Fort Worth, Texas, USA.
  • Caso C; University of Washington, Seattle, Washington, USA.
  • Coppola G; University of California Los Angeles, Los Angeles, California, USA.
  • Dever R; University of California San Francisco, San Francisco, California, USA.
  • Dheel C; Mayo Clinic, Rochester, Minnesota, USA.
  • Dickerson B; Harvard University/Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Dickinson S; Association for Frontotemporal Degeneration, Radnor, Pennsylvania, USA.
  • Dominguez S; University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Domoto-Reilly K; University of Washington, Seattle, Washington, USA.
  • Faber K; National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indiana University, Indianapolis, Indiana, USA.
  • Ferrell J; University of North Carolina, Chapel Hill, North Carolina, USA.
  • Fishman A; Johns Hopkins University, Baltimore, Maryland, USA.
  • Fong J; University of California San Francisco, San Francisco, California, USA.
  • Foroud T; National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indiana University, Indianapolis, Indiana, USA.
  • Gavrilova R; Mayo Clinic, Rochester, Minnesota, USA.
  • Gearhart D; Mayo Clinic, Rochester, Minnesota, USA.
  • Ghazanfari B; University of Toronto, Toronto, Ontario, Canada.
  • Ghoshal N; Washington University, St. Louis, Missouri, USA.
  • Goldman JS; Columbia University, New York, New York, USA.
  • Graff-Radford J; Mayo Clinic, Rochester, Minnesota, USA.
  • Graff-Radford N; Mayo Clinic, Jacksonville, Florida, USA.
  • Grant I; Northwestern University, Chicago, Illinois, USA.
  • Grossman M; University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Haley D; Mayo Clinic, Jacksonville, Florida, USA.
  • Hsiung R; University of British Columbia, Vancouver, British Columbia, Canada.
  • Huey E; Columbia University, New York, New York, USA.
  • Irwin D; University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Jones D; Mayo Clinic, Rochester, Minnesota, USA.
  • Jones L; Washington University, St. Louis, Missouri, USA.
  • Kantarci K; Mayo Clinic, Rochester, Minnesota, USA.
  • Karydas A; University of California San Francisco, San Francisco, California, USA.
  • Kaufer D; University of North Carolina, Chapel Hill, North Carolina, USA.
  • Kerwin D; University of Texas Southwestern, Dallas, Texas, USA.
  • Kraft R; Mayo Clinic, Rochester, Minnesota, USA.
  • Kramer J; University of California San Francisco, San Francisco, California, USA.
Alzheimers Dement ; 16(1): 106-117, 2020 01.
Article em En | MEDLINE | ID: mdl-31914218
ABSTRACT

INTRODUCTION:

We created global rating scoring rules for the CDR® plus NACC FTLD to detect and track early frontotemporal lobar degeneration (FTLD) and to conduct clinical trials in FTLD.

METHODS:

The CDR plus NACC FTLD rating was applied to 970 sporadic and familial participants from the baseline visit of Advancing Research and Treatment in Frontotemporal Lobar Degeneration (ARTFL)/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS). Each of the eight domains of the CDR plus NACC FTLD was equally weighed in determining the global score. An interrater reliability study was completed for 40 participants.

RESULTS:

The CDR plus NACC FTLD showed very good interrater reliability. It was especially useful in detecting clinical features of mild non-fluent/agrammatic variant primary progressive aphasia participants.

DISCUSSION:

The global CDR plus NACC FTLD score could be an attractive outcome measure for clinical trials in symptomatic FTLD, and may be useful in natural history studies and clinical trials in FTLD spectrum disorders.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Afasia Primária Progressiva / Degeneração Lobar Frontotemporal / Testes de Estado Mental e Demência Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Afasia Primária Progressiva / Degeneração Lobar Frontotemporal / Testes de Estado Mental e Demência Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article