Subjects with microvascular angina have longer GT repeats polymorphism in the haem oxygenase-1 gene promoter.
Biomarkers
; 25(2): 144-148, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-31916865
ABSTRACT
Objective:
Few studies have investigated haem oxygenase-1 gene (HMOX1) promoter polymorphism in microvascular angina (MVA).Materials andmethods:
HMOX1 promoter (GT)n repeats were examined in healthy controls (N = 220) and MVA subjects (N = 181).Results:
The distribution of genotype of SS, SL and LL were significantly different in MVA (17%, 51%, 33%) vs. normal controls (35%, 46%, 20%) (p < 0.001, S allele ≤30 repeats, L allele >30 repeats). In multivariate analysis, carrier of L allele (odds ratio 2.772, p < 0.001) was a significant predictor for the diagnosis of MVA.Conclusions:
Subjects with MVA had longer HMOX1 promoter (GT)n repeats than the healthy controls. Trial registration number NCT01198730 at https//clinicaltrials.gov.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Timina
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Angina Microvascular
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Heme Oxigenase-1
/
Guanina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article