Hydrogen Atom Transfer-Mediated Domino Cyclisation Reaction to Access (Spiro)Quinazolinones.

Turner, Oliver J; Hirst, David J; Murphy, John A

Turner, Oliver J; Hirst, David J; Murphy, John A.

Afiliação

Turner OJ; GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
Hirst DJ; Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G11XL, UK.
Murphy JA; GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.

Chemistry ; 26(14): 3026-3029, 2020 Mar 09.

Article em En | MEDLINE | ID: mdl-31922300

ABSTRACT

ABSTRACT

A radical domino cyclisation reaction of N-cyanamide alkenes, mediated by hydrogen atom transfer (HAT) has been developed. This method, using PhSiH3 and catalytic Fe(acac)3 , allows for the synthesis of challenging (spiro)quinazolinone scaffolds from simple, tractable (hetero)aryl carboxylic acid and cyanamide building blocks.

Palavras-chave

cyanamide; cyclisation; hydrogen transfer; iron(III); radicals

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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