Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-&#954;BTGF-ß1/Smad Signaling Pathway.

Quan, Yi; Park, Woong; Jin, Jixiu; Kim, Won; Park, Sung Kwang; Kang, Kyung Pyo

Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-κBTGF-ß1/Smad Signaling Pathway.

Quan, Yi; Park, Woong; Jin, Jixiu; Kim, Won; Park, Sung Kwang; Kang, Kyung Pyo.

Afiliação

Quan Y; Department of Internal Medicine, Research Institute of Clinical Medicine, Jeonbuk National UniversityMedical School, Jeonju 54907, Korea.
Park W; Department of Internal Medicine, Research Institute of Clinical Medicine, Jeonbuk National UniversityMedical School, Jeonju 54907, Korea.
Jin J; Department of Internal Medicine, Research Institute of Clinical Medicine, Jeonbuk National UniversityMedical School, Jeonju 54907, Korea.
Kim W; Department of Internal Medicine, Research Institute of Clinical Medicine, Jeonbuk National UniversityMedical School, Jeonju 54907, Korea.
Park SK; Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju 54907, Korea.
Kang KP; Department of Internal Medicine, Research Institute of Clinical Medicine, Jeonbuk National UniversityMedical School, Jeonju 54907, Korea.

Int J Mol Sci ; 21(2)2020 Jan 08.

Article em En | MEDLINE | ID: mdl-31936371

Assuntos

Fibrose/tratamento farmacológico; Inflamação/tratamento farmacológico; Nefropatias/tratamento farmacológico; Sirtuína 3/genética; Fator de Crescimento Transformador beta1/genética; Animais; Compostos de Bifenilo/farmacologia; Linhagem Celular; Modelos Animais de Doenças; Fibrose/genética; Fibrose/patologia; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Inflamação/genética; Inflamação/patologia; Nefropatias/genética; Nefropatias/patologia; Lignanas/farmacologia; Camundongos; Dinâmica Mitocondrial/efeitos dos fármacos; NF-kappa B/genética; Transdução de Sinais/efeitos dos fármacos; Proteínas Smad/genética

Palavras-chave

Sirtuin 3; extracellular matrix; inflammation; kidney fibrosis; mitochondrial dynamics; myofibroblast activation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose / Fator de Crescimento Transformador beta1 / Sirtuína 3 / Inflamação / Nefropatias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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