Photothermal-Promoted Morphology Transformation in Vivo Monitored by Photoacoustic Imaging.
Nano Lett
; 20(2): 1286-1295, 2020 02 12.
Article
em En
| MEDLINE
| ID: mdl-31940203
ABSTRACT
The in situ construction of the nanoassembly has been demonstrated to improve the performance of bioactive molecules, but the control of the morphology of nanomaterials in vivo still remains a tremendous challenge. Herein, a photothermal-promoted morphology transformation (PMT) strategy is developed to accelerate the formation of nanomaterials for improving the biological performance of drug molecules. Compared with the spontaneous process, the rate of transformation increases by â¼4 times in the PMT process. Owing to increased assembly rate, the tumor accumulation of drugs is â¼2-fold than that without photo irradiation, which inhibits tumor growth effectively. More importantly, the chemical reassembly process in vitro and in vivo is monitored by the advanced ratiometric photoacoustic image, confirming the photoinduced transformation acceleration. Through the noninvasively artificial control on assembly dynamics in vivo, the PMT strategy provides a new insight for developing the intelligent theranostics.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Diagnóstico por Imagem
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Técnicas Fotoacústicas
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Neoplasias
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Antineoplásicos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article