Deep inspirations attenuate postprandial airway inflammation in college-aged adults with elevated baseline exhaled nitric oxide: A pilot study.
Exp Lung Res
; 46(1-2): 32-43, 2020.
Article
em En
| MEDLINE
| ID: mdl-31941389
ABSTRACT
Airway inflammation (assessed by exhaled nitric oxide (eNO)) increases after a single high-fat meal (HFM), yet this response may be modified by airway stretch and baseline eNO level.Purpose:
The purpose of this study was to investigate whether deep inspirations (DIs) would attenuate airway inflammation post-HFM and whether this is modulated by baseline eNO level.Methods:
A total of sixteen healthy college-aged participants completed a randomized cross-over study with 8 lower eNO (14.8 ± 2.0 ppb 3 M/5F; age 22.0 ± 2.2 yrs) and 8 higher eNO (29.3 ± 11.6 ppb 5 M/3F; age 22.5 ± 2.6 yrs) participants. All participants completed a control (CON) condition (no DIs pre-HFM) and DI condition (60 DI's to total lung capacity immediately pre-HFM) after an overnight fast. The primary outcome was eNO. Participants had 20 minutes to consume the HFM (1 g fat/1 kg body weight) and eNO was performed at 2- and 4- hours post-HFM. To determine whether baseline eNO levels impacted the effect of DI's, a median split was performed on their baseline eNO level.Results:
There was a significant increase in eNO as a main effect of time (p < 0.001). However when analyzing the potential effect of baseline eNO, there was no significant increase in eNO post-HFM in the higher eNO group in the DI condition (p = 0.54). DIs modified the eNO response to a HFM in the group with a higher baseline eNO value.Conclusions:
These data display a possible bronchoprotective protect of DIs against postprandial airway inflammation in participants with higher initial eNO level.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Pneumonia
/
Inalação
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Período Pós-Prandial
/
Óxido Nítrico
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article