A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1.

Tarr, Sarah J; Withers-Martinez, Chrislaine; Flynn, Helen R; Snijders, Ambrosius P; Masino, Laura; Koussis, Konstantinos; Conway, David J; Blackman, Michael J

Tarr, Sarah J; Withers-Martinez, Chrislaine; Flynn, Helen R; Snijders, Ambrosius P; Masino, Laura; Koussis, Konstantinos; Conway, David J; Blackman, Michael J.

Afiliação

Tarr SJ; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.
Withers-Martinez C; Malaria Biochemistry Laboratory, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, U.K.
Flynn HR; Protein Analysis and Proteomics Platform, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, U.K.
Snijders AP; Protein Analysis and Proteomics Platform, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, U.K.
Masino L; Structural Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, U.K.
Koussis K; Malaria Biochemistry Laboratory, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, U.K.
Conway DJ; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.
Blackman MJ; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.

Biochem J ; 477(2): 525-540, 2020 01 31.

Article em En | MEDLINE | ID: mdl-31942933

Assuntos

Malária Falciparum/genética; Plasmodium falciparum/genética; Serina Proteases/química; Subtilisina/genética; Sequência de Aminoácidos/genética; Animais; Eritrócitos/parasitologia; Genoma/genética; Humanos; Estágios do Ciclo de Vida/genética; Malária Falciparum/enzimologia; Malária Falciparum/parasitologia; Peptídeo Hidrolases/química; Peptídeo Hidrolases/genética; Plasmodium falciparum/patogenicidade; Proteólise; Proteínas de Protozoários/química; Proteínas de Protozoários/genética; Serina Proteases/genética; Subtilisina/química; Vacúolos/parasitologia

Palavras-chave

Plasmodium falciparum; parasitophorous vacuole; propeptide; subtilase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Malária Falciparum / Subtilisina / Serina Proteases Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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