Dimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO-1 signaling pathway.

Gu, Lingwen; Lin, Jing; Wang, Qian; Li, Cui; Peng, Xudong; Fan, Yiqun; Lu, Chunli; Lin, Hao; Niu, Yawen; Zhu, Guoqiang; Zhao, Guiqiu

Gu, Lingwen; Lin, Jing; Wang, Qian; Li, Cui; Peng, Xudong; Fan, Yiqun; Lu, Chunli; Lin, Hao; Niu, Yawen; Zhu, Guoqiang; Zhao, Guiqiu.

Afiliação

Gu L; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Lin J; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Wang Q; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Li C; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Peng X; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Fan Y; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Lu C; Department of Medicine, Qingdao University, Qingdao, China.
Lin H; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Niu Y; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhu G; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhao G; Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Immunol Cell Biol ; 98(3): 229-241, 2020 03.

Article em En | MEDLINE | ID: mdl-31943336

Assuntos

Aspergilose/tratamento farmacológico; Aspergillus fumigatus/efeitos dos fármacos; Epitélio Corneano/efeitos dos fármacos; Heme Oxigenase-1/metabolismo; Ceratite/tratamento farmacológico; Fator 2 Relacionado a NF-E2/metabolismo; Transdução de Sinais/efeitos dos fármacos; Succinatos/farmacologia; Animais; Aspergilose/metabolismo; Aspergillus fumigatus/imunologia; Aspergillus fumigatus/metabolismo; Quimiocina CXCL1/metabolismo; Córnea/efeitos dos fármacos; Córnea/microbiologia; Córnea/patologia; Células Epiteliais/efeitos dos fármacos; Células Epiteliais/metabolismo; Epitélio Corneano/metabolismo; Epitélio Corneano/microbiologia; Humanos; Inflamação/tratamento farmacológico; Interleucina-6/metabolismo; Interleucina-8/metabolismo; Ceratite/metabolismo; Camundongos; Succinatos/uso terapêutico

Palavras-chave

Dimethyl itaconate; fungal keratitis; inflammation; treatment

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergilose / Aspergillus fumigatus / Succinatos / Transdução de Sinais / Epitélio Corneano / Heme Oxigenase-1 / Fator 2 Relacionado a NF-E2 / Ceratite Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google