Stereoselective Allylic Alkylations of Amino Ketones and Their Application in the Synthesis of Highly Functionalized Piperidines.

Prudel, Cynthia; Huwig, Kai; Kazmaier, Uli

Prudel, Cynthia; Huwig, Kai; Kazmaier, Uli.

Afiliação

Prudel C; Organic Chemistry, Saarland University, Campus C4.2, 66123, Saarbrücken, Germany.
Huwig K; Organic Chemistry, Saarland University, Campus C4.2, 66123, Saarbrücken, Germany.
Kazmaier U; Organic Chemistry, Saarland University, Campus C4.2, 66123, Saarbrücken, Germany.

Chemistry ; 26(14): 3181-3188, 2020 Mar 09.

Article em En | MEDLINE | ID: mdl-31943413

ABSTRACT

ABSTRACT

Chelated ketone enolates are excellent nucleophiles for allylic alkylations. Electron-withdrawing groups on the allyl moiety allow subsequent intramolecular Michael additions giving rise to piperidines with up to five stereogenic centers.

Palavras-chave

allylic alkylation; chelates; enolates; ketones; palladium; piperidines

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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