Suppression of tooth movement-induced sclerostin expression using ß-adrenergic receptor blockers.
Oral Dis
; 26(3): 621-629, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-31943597
ABSTRACT
OBJECTIVE:
Regulation of bone metabolism by the sympathetic nervous system has recently been clarified. Tooth movement is increased by increased bone metabolic turnover due to sympathetic activation. This study aimed to compare the effects of the ß-adrenergic receptor (ß-AR) blockers atenolol (ß1-AR blocker), butoxamine (ß2-AR blocker) and propranolol (non-selective ß-AR blocker) on tooth movement in spontaneously hypertensive rats (SHR) with sympathicotonia. MATERIALS ANDMETHODS:
Spontaneously hypertensive rats were divided into the following four groups an SHR control group and groups treated with 0.1 mg/kg atenolol, 1 mg/kg butoxamine or 1 mg/kg propranolol (n = 6 rats/group). Atenolol, butoxamine or propranolol was administered daily to each treatment group, and orthodontic force was applied using a closed-coil spring. Finally, immunohistochemical analysis was performed for receptor activator of nuclear factor kappa-B ligand (RANKL) and sclerostin (SOST).RESULTS:
Atenolol, butoxamine and propranolol inhibited tooth movement and increased maxillary alveolar bone volume. Histological analysis revealed that these ß-AR blockers decreased osteoclast activity on the compression side. Furthermore, immunohistochemical analysis revealed that atenolol, butoxamine and propranolol decreased the number of RANKL- and SOST-positive osteocytes on the compression side.CONCLUSIONS:
ß-AR blockers decreased tooth movement and downregulated SOST in osteocytes, accompanied by increasing alveolar bone resorption.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Técnicas de Movimentação Dentária
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Antagonistas Adrenérgicos beta
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Proteínas Morfogenéticas Ósseas
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article