The highly selective mGlu<sub>2</sub> receptor positive allosteric modulator LY-487,379 alleviates l-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson's disease.

Hamadjida, Adjia; Sid-Otmane, Lamia; Kwan, Cynthia; Frouni, Imane; Nafade, Vaidehi; Bédard, Dominique; Gagnon, Dave; Wallman, Marie-Josée; Rouillard, Claude; Parent, André; Parent, Martin; Huot, Philippe

The highly selective mGlu₂ receptor positive allosteric modulator LY-487,379 alleviates l-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson's disease.

Hamadjida, Adjia; Sid-Otmane, Lamia; Kwan, Cynthia; Frouni, Imane; Nafade, Vaidehi; Bédard, Dominique; Gagnon, Dave; Wallman, Marie-Josée; Rouillard, Claude; Parent, André; Parent, Martin; Huot, Philippe.

Afiliação

Hamadjida A; Neurodegenerative Disease Group, Montreal Neurological Institute, Montreal, QC, Canada.
Sid-Otmane L; Département de Pharmacologie et Physiologie, Université de Montréal, Montreal, QC, Canada.
Kwan C; Neurodegenerative Disease Group, Montreal Neurological Institute, Montreal, QC, Canada.
Frouni I; Neurodegenerative Disease Group, Montreal Neurological Institute, Montreal, QC, Canada.
Nafade V; Département de Pharmacologie et Physiologie, Université de Montréal, Montreal, QC, Canada.
Bédard D; Neurodegenerative Disease Group, Montreal Neurological Institute, Montreal, QC, Canada.
Gagnon D; Neurodegenerative Disease Group, Montreal Neurological Institute, Montreal, QC, Canada.
Wallman MJ; Centre de Recherche CERVO, Quebec City, QC, Canada.
Rouillard C; Centre de Recherche CERVO, Quebec City, QC, Canada.
Parent A; Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec City, QC, Canada.
Parent M; Centre de Recherche CERVO, Quebec City, QC, Canada.
Huot P; Centre de Recherche CERVO, Quebec City, QC, Canada.

Eur J Neurosci ; 51(12): 2412-2422, 2020 06.

Article em En | MEDLINE | ID: mdl-31944461

Assuntos

Discinesia Induzida por Medicamentos; Doença de Parkinson; Animais; Antiparkinsonianos; Callithrix; Modelos Animais de Doenças; Discinesia Induzida por Medicamentos/tratamento farmacológico; Levodopa; Oxidopamina/toxicidade; Ratos

Palavras-chave

LY-487,379; Parkinson's disease; dyskinesia; l-DOPA; mGlu2 receptor; positive allosteric modulator

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Discinesia Induzida por Medicamentos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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