Molty-Level Regulation: Lysosomes Participate in Developmental ECM Remodeling in C. elegans.

ABSTRACT

Dynamic regulation of lysosomes allows them to play key roles in cell and tissue homeostasis. In this issue of Developmental Cell, Miao et al. find that a novel transcriptional pathway triggered by loss of cell adhesion activates lysosomes in C. elegans epidermis during developmental remodeling of the cuticle.