Correlation between glucose metabolism and serum steroid hormones in patients with polycystic ovary syndrome.
Clin Endocrinol (Oxf)
; 92(4): 350-357, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-31954081
ABSTRACT
OBJECTIVE:
Polycystic ovary syndrome (PCOS) is associated with an increased prevalence of dysglycaemia, which includes impaired glucose tolerance and type 2 diabetes mellitus (T2DM). Patients with PCOS demonstrate abnormal patterns of steroid hormones. Here, we analyse the correlation between glucose metabolism and serum steroid hormones in PCOS.DESIGN:
Observational double-centre study. PATIENTS 914 patients with PCOS. MEASUREMENTS We assessed the glucose metabolism status of all patients according to the 1999 WHO criteria. Serum steroid hormones were measured by liquid chromatography-tandem mass spectrometry.RESULTS:
The median age of the patients was 26 years (interquartile range 21-30), and 40.6% (371/914) had abnormal glucose metabolism 29.3% (268/914) had prediabetes, and 11.3% (103/914) had T2DM. Correlation analysis not adjusting for confounding factors revealed that serum aldosterone, androstenedione, oestrone, pregnenolone and the free androgen index were positively correlated, while progesterone was negatively correlated with the risk of abnormal glucose metabolism. After adjusting for age, body mass index and fasting insulin levels in the logistic regression model, only aldosterone (P = .013), androstenedione (P = .046) and oestrone (P = .014; in quartiles) were correlated with the risk of abnormal glucose metabolism.CONCLUSIONS:
This study indicates a high prevalence of prediabetes and T2DM in patients with PCOS. Furthermore, there were positive correlations of serum aldosterone, androstenedione and oestrone with the risk of abnormal glucose metabolism after adjusting for confounding factors.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
/
Diabetes Mellitus Tipo 2
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
/
Newborn
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article