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Colorectal cancer and trace elements alteration.
Juloski, Jovan T; Rakic, Aleksandar; Cuk, Vladica V; Cuk, Vladimir M; Stefanovic, Srdan; Nikolic, Dragica; Jankovic, Sasa; Trbovich, Alexander M; De Luka, Silvio R.
Afiliação
  • Juloski JT; Zvezdara Medical University Center, Surgery Clinic "Nikola Spasic", Dimitrija Tucovica 161, 11000 Belgrade, Serbia. Electronic address: jovan.juloski@gmail.com.
  • Rakic A; Department of Pathological Physiology, Faculty of Medicine, University of Belgrade, Dr Subotica 1, 11000 Belgrade, Serbia. Electronic address: aleksandar.rakic@med.bg.ac.rs.
  • Cuk VV; Zvezdara Medical University Center, Surgery Clinic "Nikola Spasic", Dimitrija Tucovica 161, 11000 Belgrade, Serbia. Electronic address: vladicacuk@gmail.com.
  • Cuk VM; Zvezdara Medical University Center, Surgery Clinic "Nikola Spasic", Dimitrija Tucovica 161, 11000 Belgrade, Serbia. Electronic address: cuk_cusa@yahoo.com.
  • Stefanovic S; Institute of Meat Hygiene and Technology, Kacanskog 13, 11000 Belgrade, Serbia. Electronic address: srdjan.stefanovic@inmes.rs.
  • Nikolic D; Institute of Meat Hygiene and Technology, Kacanskog 13, 11000 Belgrade, Serbia. Electronic address: dragica.nikolic@inmes.rs.
  • Jankovic S; Institute of Meat Hygiene and Technology, Kacanskog 13, 11000 Belgrade, Serbia. Electronic address: sasa.jankovic@inmes.rs.
  • Trbovich AM; Department of Pathological Physiology, Faculty of Medicine, University of Belgrade, Dr Subotica 1, 11000 Belgrade, Serbia. Electronic address: alexander.m.trbovich@gmail.com.
  • De Luka SR; Department of Pathological Physiology, Faculty of Medicine, University of Belgrade, Dr Subotica 1, 11000 Belgrade, Serbia. Electronic address: silvio.de-luka@med.bg.ac.rs.
J Trace Elem Med Biol ; 59: 126451, 2020 May.
Article em En | MEDLINE | ID: mdl-31954212
BACKGROUND: Trace elements have important influence on body function primarily because of the vital role they have in many physiological processes. Their alterations have been found in many disorders, including cancer. It has been well known for decades that disturbances in elemental concentration may lead to cell damaging, DNA injuries and imbalance in oxidative burden. Our study tried to determine the difference of trace elements concentrations between colorectal adenocarcinoma and adjacent healthy intestinal tissue. METHODS: 59 subjects participated in this study. Healthy colon mucosa samples and colon tumor tissue samples were obtained from patients previously diagnosed with colon carcinoma by standard diagnostic procedures. Analysis of the elements was performed by inductively coupled plasma mass spectrometry (ICP-MS). RESULTS: The results showed that Na, K, Mg, Ca, Cu, Zn, Se, Mn, Cd, Cr and Hg significantly differ between malignant tissue of colorectal cancer (CRC) and adjacent healthy bowel tissue. We have, also, found that Cu/Zn tissue ratio was significantly higher in CRC compared to a healthy tissue and that patients with higher CRC stages had also significantly higher ratio. CONCLUSIONS: Since this is the first such study in Balkan region, we assume that results of our study could be a good indicator of elemental alterations in colorectal cancer of Balkan population, due to similarity in lifestyle, dietary intake, pollution and exposure to toxic elements.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligoelementos / Neoplasias Colorretais / Colo Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligoelementos / Neoplasias Colorretais / Colo Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article