Your browser doesn't support javascript.
loading
Incorporating Thiourea into Fluorescent Probes: A Reliable Strategy for Mitochondrion-Targeted Imaging and Superoxide Anion Tracking in Living Cells.
Wang, Tao; Shah, Imran; Yang, Zengming; Yin, Weidong; Zhang, Shaoxiong; Yang, Yuan; Yin, Pei; Ma, Hengchang.
Afiliação
  • Wang T; Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou 730070 , China.
  • Shah I; Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou 730070 , China.
  • Yang Z; Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou 730070 , China.
  • Yin W; Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou 730070 , China.
  • Zhang S; Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou 730070 , China.
  • Yang Y; Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou 730070 , China.
  • Yin P; Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou 730070 , China.
  • Ma H; Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou 730070 , China.
Anal Chem ; 92(3): 2824-2829, 2020 02 04.
Article em En | MEDLINE | ID: mdl-31957439
ABSTRACT
Three aggregation-induced emission active fluorescent compounds, TPA-Pyr-Octane, TPA-Pyr-Br, and TPA-Pyr-Thiourea (TPA = triphenylamine pyridinium), are synthesized; their tiny differences in chemical structures result in a huge difference in cell-imaging applications. Especially, incorporating thiourea into fluorescent probes is found as a reliable strategy for mitochondrion-targeted imaging and superoxide anion tracking in living cells, which is possibly due to the presence of hydrogen bonding between thiourea and mitochondrion proteins. This finding is very useful for the design of biosensors and delivery carriers in disease treatment.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tioureia / Superóxidos / Imagem Óptica / Corantes Fluorescentes / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tioureia / Superóxidos / Imagem Óptica / Corantes Fluorescentes / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article