DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis.

van der Stoel, Miesje; Schimmel, Lilian; Nawaz, Kalim; van Stalborch, Anne-Marieke; de Haan, Annett; Klaus-Bergmann, Alexandra; Valent, Erik T; Koenis, Duco S; van Nieuw Amerongen, Geerten P; de Vries, Carlie J; de Waard, Vivian; Gloerich, Martijn; van Buul, Jaap D; Huveneers, Stephan

van der Stoel, Miesje; Schimmel, Lilian; Nawaz, Kalim; van Stalborch, Anne-Marieke; de Haan, Annett; Klaus-Bergmann, Alexandra; Valent, Erik T; Koenis, Duco S; van Nieuw Amerongen, Geerten P; de Vries, Carlie J; de Waard, Vivian; Gloerich, Martijn; van Buul, Jaap D; Huveneers, Stephan.

Afiliação

van der Stoel M; Amsterdam UMC, University of Amsterdam, location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands.
Schimmel L; Sanquin Research and Landsteiner Laboratory, Department of Molecular and Cellular Hemostasis, University of Amsterdam, 1066 CX Amsterdam, The Netherlands.
Nawaz K; Sanquin Research and Landsteiner Laboratory, Department of Molecular and Cellular Hemostasis, University of Amsterdam, 1066 CX Amsterdam, The Netherlands.
van Stalborch AM; Sanquin Research and Landsteiner Laboratory, Department of Molecular and Cellular Hemostasis, University of Amsterdam, 1066 CX Amsterdam, The Netherlands.
de Haan A; Amsterdam UMC, University of Amsterdam, location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands.
Klaus-Bergmann A; Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany.
Valent ET; DZHK (German Center for Cardiovascular Research), 10785 Berlin, Germany.
Koenis DS; Amsterdam UMC, Free University, location VUMC, Department of Physiology, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands.
van Nieuw Amerongen GP; Amsterdam UMC, University of Amsterdam, location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands.
de Vries CJ; Amsterdam UMC, Free University, location VUMC, Department of Physiology, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands.
de Waard V; Amsterdam UMC, University of Amsterdam, location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands.
Gloerich M; Amsterdam UMC, University of Amsterdam, location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands.
van Buul JD; University Medical Center Utrecht, Center for Molecular Medicine, Dept. Molecular Cancer Research, 3584 CX Utrecht, The Netherlands.
Huveneers S; Sanquin Research and Landsteiner Laboratory, Department of Molecular and Cellular Hemostasis, University of Amsterdam, 1066 CX Amsterdam, The Netherlands.

J Cell Sci ; 133(3)2020 02 12.

Article em En | MEDLINE | ID: mdl-31964713

Assuntos

Proteínas Adaptadoras de Transdução de Sinal; Células Endoteliais; Proteínas Adaptadoras de Transdução de Sinal/genética; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Células Endoteliais/metabolismo; Proteínas Ativadoras de GTPase/genética; Humanos; Morfogênese; Neovascularização Patológica; Fosfoproteínas/genética; Fosfoproteínas/metabolismo; Transdução de Sinais; Proteínas Supressoras de Tumor/genética

Palavras-chave

Adhesion; Angiogenesis; Endothelium; Integrin; Mechanotransduction; YAP

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Endoteliais / Proteínas Adaptadoras de Transdução de Sinal Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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