Quantitative Muscle MRI Protocol as Possible Biomarker in Becker Muscular Dystrophy.
Clin Neuroradiol
; 31(1): 257-266, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-31974637
ABSTRACT
PURPOSE:
Aim of this study is to compare Quantitative Magnetic Resonance Imaging (qMRI) measures between Becker Muscular Dystrophy (BMD) and Healthy Subjects (HS) and to correlate these parameters with clinical scores.METHODS:
Ten BMD patients (mean age ±standard deviation 38.7⯱ 15.0 years) and ten age-matched HS, were investigated through magnetic resonance imaging (MRI) at thigh and calf levels, including 1) a standard axial T1-weighted sequence; 2) a volumetric T2-weighted sequence; 3) a multiecho spin-echo sequence; 4) a 2-point Dixon sequence; 5) a Diffusion Tensor Imaging (DTI) sequence.RESULTS:
Mean Fat Fraction (FF), T2-relaxation time and Fractional Anisotropy (FA) DTI at thigh and calf levels were significantly higher in BMD patients than in HS (p-values < 0.01). FF at thigh and calf levels significantly correlated with North Star Ambulatory Assessment (NSAA) score (p-values < 0.01) and6 Minutes Walking Test (6MWT) (p-values < 0.01), whereas only calf muscle FF was significantly associated with time to get up from floor (p-valueâ¯= 0.01). T2 significantly correlated with NSAA score (p-value < 0.01), 6MWT (p-valueâ¯= 0.02) and time to get up from floor (p-value < 0.01) only at calf level. Among DTI values, only FA in thigh and calf muscles significantly correlated with NSAA score, 6MWT and 10-m walk (all p-values < 0.05); only FA in calf muscles significantly correlated with time to get up from floor (pâ¯= 0.01).CONCLUSIONS:
Muscle FF, T2-relaxometry and DTI, seem to be a promising biomarker to assess BMD disease severity, although further studies are needed to evaluate changes over the time.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Distrofia Muscular de Duchenne
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article