Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells.

Hong, Junmin; Li, Shuangxing; Markova, Dessislava Z; Liang, Anjing; Kepler, Christopher K; Huang, Yingjie; Zhou, Jie; Yan, Jiansen; Chen, Weijian; Huang, Dongsheng; Xu, Kang; Ye, Wei

Hong, Junmin; Li, Shuangxing; Markova, Dessislava Z; Liang, Anjing; Kepler, Christopher K; Huang, Yingjie; Zhou, Jie; Yan, Jiansen; Chen, Weijian; Huang, Dongsheng; Xu, Kang; Ye, Wei.

Afiliação

Hong J; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Li S; Department of Spine Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Markova DZ; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Liang A; Department of Spine Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Kepler CK; Department of Orthopedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
Huang Y; Department of Spine Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Zhou J; Department of Orthopedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
Yan J; Department of Spine Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Chen W; Department of Orthopedics, The fifth affiliated hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Huang D; Department of Breast Cancer Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong, China.
Xu K; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Ye W; Department of Spine Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

J Cell Physiol ; 235(7-8): 5736-5749, 2020 07.

Article em En | MEDLINE | ID: mdl-31975410

Assuntos

Inflamação/genética; Degeneração do Disco Intervertebral/genética; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Proteínas Nucleares/genética; Fator de Transcrição RelA/genética; Fatores de Transcrição/genética; Animais; Autofagia/genética; Azepinas/farmacologia; Modelos Animais de Doenças; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Inflamassomos/efeitos dos fármacos; Inflamação/patologia; Degeneração do Disco Intervertebral/patologia; Macrolídeos/farmacologia; NF-kappa B/genética; Núcleo Pulposo/metabolismo; Núcleo Pulposo/patologia; Ratos; Transdução de Sinais/efeitos dos fármacos; Triazóis/farmacologia

Palavras-chave

BRD4; NF-κB signaling; NLRP3 inflammasome activity; autophagy; inflammatory cytokine; intervertebral disc degeneration

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Fator de Transcrição RelA / Degeneração do Disco Intervertebral / Proteína 3 que Contém Domínio de Pirina da Família NLR / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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