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The Endocannabinoid System: A Target for Cancer Treatment.
Laezza, Chiara; Pagano, Cristina; Navarra, Giovanna; Pastorino, Olga; Proto, Maria Chiara; Fiore, Donatella; Piscopo, Chiara; Gazzerro, Patrizia; Bifulco, Maurizio.
Afiliação
  • Laezza C; Institute of Endocrinology and Experimental Oncology, IEOS CNR, 80131 Naples, Italy.
  • Pagano C; Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.
  • Navarra G; Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.
  • Pastorino O; Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.
  • Proto MC; Department of Pharmacy, University of Salerno, 84084 Fisciano (SA), Italy.
  • Fiore D; Department of Pharmacy, University of Salerno, 84084 Fisciano (SA), Italy.
  • Piscopo C; Department of Pharmacy, University of Salerno, 84084 Fisciano (SA), Italy.
  • Gazzerro P; Department of Pharmacy, University of Salerno, 84084 Fisciano (SA), Italy.
  • Bifulco M; Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.
Int J Mol Sci ; 21(3)2020 Jan 23.
Article em En | MEDLINE | ID: mdl-31979368
ABSTRACT
In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canabinoides / Movimento Celular / Receptores de Canabinoides / Endocanabinoides / Neoplasias / Neovascularização Patológica / Antineoplásicos Tipo de estudo: Guideline Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canabinoides / Movimento Celular / Receptores de Canabinoides / Endocanabinoides / Neoplasias / Neovascularização Patológica / Antineoplásicos Tipo de estudo: Guideline Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article