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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aß42:Aß40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.
Meilandt, William J; Ngu, Hai; Gogineni, Alvin; Lalehzadeh, Guita; Lee, Seung-Hye; Srinivasan, Karpagam; Imperio, Jose; Wu, Tiffany; Weber, Martin; Kruse, Agatha J; Stark, Kimberly L; Chan, Pamela; Kwong, Mandy; Modrusan, Zora; Friedman, Brad A; Elstrott, Justin; Foreman, Oded; Easton, Amy; Sheng, Morgan; Hansen, David V.
Afiliação
  • Meilandt WJ; Departments of Neuroscience, hansen.david@gene.com meilandt.william@gene.com.
  • Ngu H; Pathology.
  • Gogineni A; Biomedical Imaging.
  • Lalehzadeh G; Departments of Neuroscience.
  • Lee SH; Departments of Neuroscience.
  • Srinivasan K; Departments of Neuroscience.
  • Imperio J; Departments of Neuroscience.
  • Wu T; Departments of Neuroscience.
  • Weber M; Departments of Neuroscience.
  • Kruse AJ; Biomedical Imaging.
  • Stark KL; Departments of Neuroscience.
  • Chan P; Biochemical and Cellular Pharmacology, and.
  • Kwong M; Biochemical and Cellular Pharmacology, and.
  • Modrusan Z; Molecular Biology, Genentech, Inc., South San Francisco, California 94080.
  • Friedman BA; Bioinformatics.
  • Elstrott J; Biomedical Imaging.
  • Foreman O; Pathology.
  • Easton A; Departments of Neuroscience.
  • Sheng M; Departments of Neuroscience.
  • Hansen DV; Departments of Neuroscience, hansen.david@gene.com meilandt.william@gene.com.
J Neurosci ; 40(9): 1956-1974, 2020 02 26.
Article em En | MEDLINE | ID: mdl-31980586
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Axônios / Glicoproteínas de Membrana / Receptores Imunológicos / Peptídeos beta-Amiloides / Precursor de Proteína beta-Amiloide / Placa Amiloide / Espinhas Dendríticas / Doença de Alzheimer / Fator Trefoil-1 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Axônios / Glicoproteínas de Membrana / Receptores Imunológicos / Peptídeos beta-Amiloides / Precursor de Proteína beta-Amiloide / Placa Amiloide / Espinhas Dendríticas / Doença de Alzheimer / Fator Trefoil-1 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article